R&D Program

R&D

R&D Program

Encare founders have discovered that a selective modulation of the inflammatory cascade in the days after AMI can result in significant reduction of adverse remodeling. Dr. Fatih Arslan found that in mice genetically lacking the fibronectin-EDA molecule had a slightly altered inflammatory response in the affected tissue after AMI and were significantly protected against development of chronic heart failure. These results were confirmed with specific antibodies against fibronectin-EDA.

Furthermore, studies from other groups have shown that fibronectin-EDA plays a detrimental role in injury and cerebral function in mice after stroke, murine lung fibrosis.